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13.10. Hemoglobin A1c trajectories in the first 18 months after diabetes diagnosis in the SWEET diabetes registry

P Prahalad , A Schwandt , S Besancon , M Mohan , B Obermannova , M Kershaw , R Bonfanti , A Pundziute Lycka , R Hanas , K Casteels , the SWEET Study Group

prahalad@stanford.edu Pediatr Diabetes 2022; 23: 228236. doi: 10.1111/pedi.13278Brief Summary: Analysis of the multi-national SWEET diabetes registry showed that mean HbA1c in youth is highest at diagnosis and lowest at 4 to 5 months post-diagnosis. The HbA1c trajectory was lower in countries with nationalized health insurance. High gross domestic p...

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ey0019.15-3 | Obesity | ESPEYB19

15.3. Obesity-associated GNAS mutations and the melanocortin pathway

E Mendes de Oliveira , JM Keogh , F Talbot , E Henning , R Ahmed , A Perdikari , R Bounds , N Wasiluk , V Ayinampudi , I Barroso , J Mokrosinski , D Jyothish , S Lim , S Gupta , M Kershaw , C Matei , P Partha , T Randell , A McAulay , LC Wilson , T Cheetham , EC Crowne , P Clayton , IS Farooqi

N Engl J Med. 2021;385(17):1581-92. doi: 10.1056/NEJMoa2103329.PubMed ID: 34614324Brief Summary: The authors performed whole exome sequencing in 2548 children with severe obesity and identified 22 GNAS mutation carriers, almost all of which disrupted melanocortin 4 receptor (MC4R) signaling.The gene GNAS encodes the stimulatory G-protein alpha subunit pr...

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ESPE Yearbook of Paediatric Endocrinology

13.10. Hemoglobin A1c trajectories in the first 18 months after diabetes diagnosis in the SWEET diabetes registry

15.3. Obesity-associated GNAS mutations and the melanocortin pathway

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